| 초록 |
Unlike DNAs and proteins, synthetic polymer involves statistical uncertainties in terms of the number and sequence of monomers. The scalable synthesis of a polymer composed of an absolutely defined aperiodic sequence remains a long-standing challenge in polymer science. Here, we report the copolymers of α-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method. Overcoming the limitations of the solid-phase synthesis of sequence-defined oligomers and polymers, our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information, 64-bit word (SEQUENCE), can be stored in an aperiodic sequence of PcL without errors, and this can be fully retrieved as binary code by tandem mass spectroscopy. Our results could enable the exploration of new properties and functions arising from the unlimited diversity of their chemical structures. |
