| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Encapsulation of conjugated polymer nanoparticles in surfactant micelle: cell imaging and photodynamic therapy |
| 초록 |
Photodynamic therapy (PDT) has appeared as device for treatment of diseases such as cancer therapy. Reactive Oxygen Species (ROS) have strong oxidizing power to attack the living tissue and cell damage through minimal invasiveness. Conjugated polymer can be potentially used in biological systems. Conjugated polymer nanoparticles (CPNs) have developed to achieve a more efficient photodynamic effect in aqueous solutions and in cells as photosensitizer. Also, we used pluronic acid as stabilizer, which been widely used to encapsulate hydrophobic therapeutic agents for drug delivery, because self-assembled polymeric micelles could dramatically improve the bioavailability of anticancer drugs by enhancing drug water solubility. This CPNs were prepared through nanoprecipitation in the presence of pluronic acid. Finally, these encapsulated CPNs showed cell image and the ROS generation under light irradiation can effectively induce photodynamic cancer therapy. |
| 저자 |
김충호1, 장근석1, 김선영2, 임용택2, 이택승1
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| 소속 |
1충남대, 2성균관대 |
| 키워드 |
photodynamic therapy; cell imaging; conjugated polymer
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| E-Mail |
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