| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
MnCO3-Mineralized Nanoparticles for US/MR Multimodal Imaging and Therapy of Cancers |
| 초록 |
Theranostic nanoparticles displaying dual functions of multimodal imaging and therapy of cancers have received growing interest. Herein, we develop a theranostic agent based on doxorubicin (DOX)-loaded MnCO3 nanoparticles (DOX-MnCO3 NPs) that can generate CO2 bubbles and Mn2+ ions for US imaging and T1 imaging, respectively, and simultaneously release DOX for cancer treatment. At physiological pH (7.4), the DOX-MnCO3 NPs would not show noticeable US and T1 MR contrast signals. In contrast, at tumoral pH (6.4), they may generate strong echogenic signals due to CO2 bubble generation and T1 signals caused by the release of Mn2+ ions. Moreover, at tumoral pH, the DOX-MnCO3 NPs would effectively release DOX for cancer treatment. These pH-activatable theranostic agents may find broad applicability for diagnosis and therapy of various cancers. |
| 저자 |
김기덕, 이평화, 이재원, 이홍재, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
theragnosis; MR imaging; US imaging; cancer therapy
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| E-Mail |
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