| 초록 |
In this study, we synthesized thermosensitive chitosan-F127-chitosan tri-block copolymer by radical polymerization. The chitosan was used narrow molecular weight distribution by fraction using ultrafiltration method. The characterization of triblock copolymer were analyzed by 1H NMR, FT-IR and SEM. The triblock copolymer showed that it was occurred sol-gel phase transition at certain temperature by hydrophobic-hydrophilic moiety balance. Its phase-transition behavior was confirmed by vial inversion method. These results suggest that chitosan-F127-chitosan tri-block copolymer can apply biomaterial field such as scaffold for cell delivery. This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Ministry of Science, ICT & Future Planning. (NRF-2014R1A2A1A10053027). |
