| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Preparation and Evaluation of Core-Crosslinking Chitosan micelles with Lipoic acid for Triggered-Drug release at Cancer cell |
| 초록 |
Reduction-sensitive reversibly core-crosslinked micelles were developed based on lipoic acid-grafted chitosan (LAC). Core-crosslinked micelles has an advantage of high stability in blood stream and triggered-drug release by glutathione into cancer cell. LAC was synthesized by coupling agent. Structural analysis of LAC was accomplished by 1H-NMR and FT-IR. In addition, Doxorubicin(DOX) was loaded to core of LAC and it was crosslinked with DTT of reduction agent. Its particle size and morphology were measured by DLS and TEM. Moreover, cytotoxicity and anticancer effect were confirmed by MTT assay. These results suggest that it can utilize as anticancer agent. This research was supported by The Leading Human Resource Training Program of Regional Neo industry through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning(grant number)(NRF-2016H1D5A1910499) |
| 저자 |
안준혁1, 최창용2, 정경원1, 홍웅길1, 나재운1
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| 소속 |
1순천대, 2한영대 |
| 키워드 |
Chitosan; Lipoic acid; Crosslinking micelles; Doxorubisin; Triggered-drug release
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| E-Mail |
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