| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Preparation and Evaluation of Pegylated-chlorambucil Prodrug nanoparticle for application as Anticancer agent |
| 초록 |
Chlorambucil(CLB) was usually used to treat leukemia disease. In a recent study, CLB exhibited to effective material in cancer therapy. However, utilization of CLB was limited because of the multi drug resistant(MDR) effect and high toxicity. Also, CLB is a insoluble in water. For these reason, we synthesized pegylated-CLB prodrug nanoparticle with coupling agent. Its chemical structure was analyzed by 1H-NMR and UV spectrophotometer, and it synthesized successfully. In addition, we measured DLS and TEM for its particle size and morphology. Moreover, cytotoxicity and anticancer effect was performed by MTT assay. These results suggest that it can apply as anticancer agent. This research was supported by The Leading Human Resource Training Program of Regional Neo industry through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning(grant number)(NRF-2016H1D5A1910499). |
| 저자 |
정은희1, 최창용2, 정경원1, 홍웅길1, 안준혁1, 나재운1
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| 소속 |
1순천대, 2한영대 |
| 키워드 |
Chlorambucil; Pegylated-chlorambucil; Prodrug; Anticancer effect
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| E-Mail |
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