| 초록 |
A biofilm formation and blood clot formation has been major issue in the field of implantable device. To overcome this problem, surface modification of the device is needed. In our previous research, we utilized facile coating method using tyrosinase that can immobilize the phenol-containing molecules onto any kind of substrates in mild aqueous condition, within short period of time. Briefly, we prepared phenol-conjugated zwitterionic poly(sulfobetaine methacrylate-co-tyramine) and graft it onto polyurethane surfaces via tyrosinase-mediated grafting method. Surface-grafted polymer was confirmed by XPS. Static water contact angle was decreased on polymer-grafted surface. Also adsorption of fibrinogen and adhesion of fibroblasts were decreased over 90% and S.aureus bacterias were decresed over 95%. In conclusion, sulfobetaine polymer grafted surface has a great potential to design a anticoagulant and antibacterial surfaces of medical devices. Acknowledgement : NRF-2015M3A9E2028577 |
