| 초록 |
Implantable medical device for recording electrophysiological signals and for stimulating muscle have been used throughout clinical medicine. However, mechanical mismatch between conventional rigid implantable device and soft muscle tissue has caused mechanical fatigue and scarring on muscle tissue. Here, we report a stretchable medical device using cell-graphene hybrid that is composed of C2C12 myoblasts and transparent mesh-patterned graphene electrodes on a buckled elastomer substrate. The graphene electrodes stimulate and monitor electrophysiological behavior of C2C12 myoblasts in vitro while act as an enhanced substrate for cellular proliferation and differentiation. The buckled topology aligns C2C12 myoblasts and provide stretchability of the hybrid. This transparent buckled cell-graphene hybrid records electromyography and stimulates target site electrically and optically in vivo. The biotic/abiotic interface between muscle tissue and the hybrid is enhanced by the integrated C2C12 myoblasts, and their proliferation within the implanted site also provide cellular therapeutic effect. Additionally, no immune response and angiogenesis are observed on the implantation site |
