| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Development of tumor microenvironment-modulating nanoparticles for improved anti-tumor efficacy of immunotherapy |
| 초록 |
Immune checkpoint blockade therapies (ICT) have revamped the cancer treatment landscape by restoring T cell effector functions. However, cancer cells have evolved to escape from this immune response by changing the tumor microenvironment (TME), which cannot induce cytotoxic T lymphocyte (CTL)-mediated immunological rejection. To address such limitations, we designed TME-modulating nanoparticles (NP@M) consisting of biocompatible polymeric shells and macitentan inside the particles. Macitentan can regulate immune-suppressing TME by inactivating cancer-associated fibroblast. TME remodeling using NP@M allowed the superior antitumor efficacy of ICT. The reduction of tumor volume was maximized in NP@M+ICT combination group. Otherwise, the number of regulatory T cells and the level of TGF-β1 were reduced in tumor site of NP@M+ICT treated group. Our findings suggested that combination therapy with NP@M can be an innovative methodology to elicit CTL-mediated immunological rejection of tumors. |
| 저자 |
손소영, 김정윤, 신솔, 김찬호, 이재아, 박재형
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| 소속 |
성균관대 |
| 키워드 |
endothelin receptor antagonist; combination therapy; immune checkpoint inhibitor; tumor microenvironment modulation; polymeric nanoparticle
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| E-Mail |
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