| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.314 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of 5-fluorouracil loaded PLGA wafer and release behavior in vitro |
| 초록 | Poly(D,L-lactide-co -glycolide) (PLGA)-based wafers offer many advantages, such as the control the drug release rate, good biocompatibility, complete biodegradation. 5-fluorouracil (5-FU) is a water-soluble drug and an antimetabolite of the pyrimidine analog type that is widely used against a variety of solid tumors with usually incorporating into microencapsulation because of its short half-life and its poor oral absorption. The aim of this study was preparation of PLGA wafers containing 5-FU and evaluation of the release kinetics from the prepared wafer in vitro. 5-FU was mixed with PLGA by Rotary evaporation method and the wafer was fabricated by direct compress method. The drug loading amount of the wafer was 10%, 20% and 30% and the size of the wafer was 3mm(diameter) by 1mm(thickness). In vitro release of 5-FU from the wafer was assayed by high performance liquid chromatography (HPLC). Morphological changes and degradation behavior of the wafer was determined by scanning electron microscopy (SEM), mass loss and water uptake observation. The prepared 5-FU loaded PLGA particles were characterized by X-ray diffractometer (XRD) and differential scanning calorimetry (DSC). Acknowledgment: This work was supported by KMOCIE(B49-990-5411-05-1-3) |
| 저자 | 이진수1, 안태군2, 유제영3, 정상영*, 강길선, 성하수*, 정제교**, 이해방* |
| 소속 | 1전북대, 2*한국화학(연), 3**삼천당제약 중앙(연) |
| 키워드 | 5-fluorouracil; PLGA; Rotary evaporation method; wafer |
