| 초록 |
Upon infection, activated neutrophils generate neutrophil extracellular traps (NETs), which trap microorganisms and pathogens, and release cytotoxic enzymes into the NET structures to kill them. Sepsis cause severe multiple organ dysfunction. In this study, We prepared polymeric NPs that were coated with PEG and DNase-I (DNPs) to pursue their prolonged circulation in the bloodstream and destroy NETs in the body, further suppress the inflammatory mediators, thereby preventing and treating sepsis. respectively. When tested under in vitro environments, the DNPs degraded DNA even at low concentrations, suggesting that the DNPs could be applicable for NET digestion in vivo. We propose that preventing NET formation by the DNPs in inflammatory or thrombotic diseases can be a potential strategy for sepsis treatment. Given this, we envision that the NET degradation with the DNPs may also reduce the lung injury, thereby improving the survival rate. |
