| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Application of Enzyme-Mediated injectable Alginate Hydrogel for wound healing in medical field |
| 초록 |
Hemostatic agents have been used in surgical operation for many years to control bleeding. In this study, we fabricated poly(vinyl pyrrolidone)(PVP) nanofibrous mats containing blood coagulation agents such as calcium chloride and thrombin to use as a novel non-woven hemostatic agent. PVP is inexpensive and safe material approved by FDA for human use. PVP nanofibrous sheets were fabricated by electrospinning of PVP aqueous ethanol solution containing thrombin and calcium chloride. PVP nanofibers showed a relatively low cytotoxicity and the cellular survival rate was more than 90%. In vitro whole blood coagulation experiment showed expeditious blood coagulation within 3 minutes after contact with fabricated nanofibrous sheet, In vivo studies using haemorrhaging liver rat model showed great promise of PVP nanofibers to aid in rapid hemostasis. These results suggest that electrospun PVP nanofibrous mats will be a promising hemostatic agent to reduce massive blood loss. |
| 저자 |
전수현, 권오형, 이승욱
|
| 소속 |
금오공과대 |
| 키워드 |
Hydrogel; wound healing; polymer
|
| E-Mail |
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