| 초록 |
Transdermal immunomodulation (TDIM) is a promising strategy to treat cancer or infectious diseases because it is not only non-invasive drug delivery but also efficient method avoiding a first pass effect. However, TDIM efficiency is generally low for difficulty of skin penetration as well as immune cell targeting. In this study, hyaluronic acid and β-glucan were hybridized via photo-crosslinking and fabricated into nanogel of which size was in the range of 150-200 nm. The hybrid nanogels efficiently penetrated porcine skin and were deposited in dermis. In dendritic cell uptake assay, the cellular uptake of the hybrid nanogel increased with an increase of β-glucan and incorporated ovalbumin (i.e., model drug) was successfully delivered to dendritic cells. |
