| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Microbubble-Self-Aggregate Complex Applied for Ultrasound-Mediated Enhanced Targeted Imaging and Drug Delivery |
| 초록 |
Microbubbles can be applied to a bifunctional material, such as drug delivery carrier and ultrasound contrast agent. Microbubble delivers the drug by conjugation of drug delivery carriers seems like nanoparticles or liposome. Under the acute ultrasound condition, the microbubble proceeds to collapse and release conjugated nanoparticles. After the microbubble is collapsed, induced strong mechanical stress can occur at the site of the blood vessel and increased permeability. It is called ‘microjet’. As using this technique, we can control drug release at the target area by the selective exposition of ultrasound. In this study, a self-assembled nanostructure loaded hydrophobic drug was chemically conjugated to microbubble. The conjugation ratio of microbubble and micelle was examined by UV-Vis spectroscopy. And the size distribution of microbubble and self-assembled nanostructure were analyzed by dynamic laser scattering(DLS). |
| 저자 |
박지호1, 안철희1, 이학종2, 정인재1, 문형원2
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| 소속 |
1서울대, 2분당서울대 |
| 키워드 |
Microbubble; drug delivery; targeted imaging
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| E-Mail |
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