| 초록 |
Even though there are many extracellular targets available for drug discovery, major target proteins are located in cytosol. As efforts to make specific drugs against these intracellular targets, larger and more specific biological modulators should be employed instead of less specific small molecule modulators. However, the biologics have own intrinsic drawbacks; they cannot get into cells by themselves and most of them need tools to translocate the biological membrane to improve their efficacies. Nanoparticle technology is one of the major tools, but short cell penetrating peptides, which are composed of 8-30 amino acids, are alternative to deliver biologics into cells. We have been designed and used amphipathic α-helical bundles dimeric peptides as excellent cell premeditating abilities at their nanomolar concentrations. Since most of biological modulators works at their nano-molar concentrations, our cell penetrating peptides are very suitable to deliver nanomolar modulators without adverse effect, which could be derived from micromolar-scale delivery of modulators. We show here several biological modulators whose efficacies are much improved by our own cell penetrating peptides for targeting various diseases, such as rheumatism, dry eye, and cancer. |
