| 초록 |
The microenvironment of tumor tissue appear to be hypoxic due to abnormal growth and metabolism of cancer cells. In hypoxic tumor, it is difficult for chemo-drug to penetrate the tumor and reduces the effectiveness of chemotherapy. Nanoparticles were synthesized using bovine serum albumin and azobenzene, which is cleavage in hypoxia condition, as a crosslinker of nanoparticle. We synthesized nanoparticles in an optimal form by controlling the amount of crosslinker. Nanoparticles show a size of about 100 nm in a normal environment, and in a hypoxia condition, they are decomposed due to the cleavage of azobenzene and the nanoparticles are degraded. It was confirmed that the higher the amount of azobenzene used to synthesize the nanoparticles, the faster the drug was released, and it was confirmed that the drug was released more in a hypoxic environment than in normal oxygen. We enable effective drug delivery system efficacy in hypoxic environment by controlling drug release by controlling the amount of azobenzene. |
