| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Cancer therapy with doxorubicin-containing hypoxiadegradation albumin nanoparticle |
| 초록 |
The microenvironment of tumor tissue appear to behypoxic due to abnormal growth and metabolism of cancer cells. In hypoxictumor, it is difficult for chemo-drug to penetrate the tumor and reduces theeffectiveness of chemotherapy.Nanoparticles were synthesized using bovineserum albumin and azobenzene, which is cleavage in hypoxia condition, as acrosslinker of nanoparticle. We synthesized nanoparticles in an optimal form bycontrolling the amount of crosslinker. Nanoparticles show a size of about 100nm in a normal environment, and in a hypoxia condition, they are decomposed dueto the cleavage of azobenzene and the nanoparticles are degraded.It wasconfirmed that the higher the amount of azobenzene used to synthesize thenanoparticles, the faster the drug was released, and it was confirmed that thedrug was released more in a hypoxic environment than in normal oxygen. |
| 저자 |
박의창, 김수헌, 이후민, 김관우, 김은수, 허윤석
|
| 소속 |
인하대 |
| 키워드 |
Hypoxia; bovine serum albumin(BSA); azobenzene
|
| E-Mail |
|
