| 초록 |
Hemagglutinin (HA), the glycoprotein in influenza virus envelope, plays a critical role in host cell entry processes. Therefore, HA is a promising target for developing anti-influenza drugs. Sialic acid (SA) has attracted attention as a candidate for the blocker. The design of multivalent receptor represents a potential strategy for inhibiting the binding of the IAV. In this study, we present a strategy for the synthesis of multivalent sialyl receptor with controlled multivalency. The binding affinities of synthetic sialyl receptors were analyzed by surface plasmon resonance (SPR). Then, we examined the interaction between synthetic sialyl receptors and influenza virus. The sialyl receptors with multivalency exhibited higher affinity than monovalent ones, thereby providing useful information on designing synthetic sialyl receptors. |
