| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy |
| 초록 |
Rationally designed biomaterial-based immune niches that can spatiotemporal modulate immunosuppressive factors in tumor microenvironment is increasingly recognized to have key roles for improving current cancer immunotherapy. Here, an implantable 3-dimensional porous scaffold was designed to generate synergistic action between myeloid-derived suppressor cell-depleting agents, which can revert an immunosuppressive microenvironment to one supporting anti-tumor immunity, and cancer vaccines consisting of whole tumor lysates and nanogel-based adjuvants, which can generate tumor antigen-specific T cell responses. The local peritumoral implantation of the synthetic immune niche (termed immuneCare-DISC, iCD) as a post-surgical treatment in an advanced-stage primary 4T1 breast tumor model generated systemic anti-tumor immunity and inhibited tumor relapse and metastasis, resulting in 100% survival. |
| 저자 |
하타이차녹풍캄, 임용택, 송찬영, 김소현, 신홍식, 이창훈
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| 소속 |
성균관대 |
| 키워드 |
cancer immunotherapy; synthetic immune niches; immunosuppression; cancer vaccine; nano-adjuvants
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| E-Mail |
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