| 초록 |
We present the syntheses of Poly[PEG methacrylate)]-b-[Poly(methacrylic acid)-r-Poly(N-isopropylacrylamide)], [PPEGMA-b-(PMAA-r-PNIPAAm)], copolymers through the reversible addition-fragmentation chain transfer (RAFT) polymerization. PMAA and PNIPAAm are well-known functional polymers that are sensitive to pH and temperature, respectively. The resulting copolymers can form a core/shell-type self-assembled nanostructure in aqueous solution depending on the solution temperature and pH due to the characteristic LCST (Lower Critical Solution Temperature) of the temperature-sensitive block. By using these polymer properties and the Fenton-like reaction with copper ions, we plan to make nanostructures with Fenton-like reaction activity depending on temperature. Hydroxyl radicals produced by the Fenton-like reaction are known to attack essential cellular components. If this reaction can occur within the tumor tissues, it will be able to destroy the tumor tissues. |
