| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 | 22권 1호, p.83 |
| 발표분야 | 고분자 |
| 제목 | Poly(pyrrole-co-aniline) nanoparticles with biocompatible amphiphilic polymer for the treatment of influenza A viral infection by controlling reactive oxygen species |
| 초록 | Current commercial antiviral agents have tolerance and serious side effects. To develop risk free antiviral agents, the correlation between viral infection and reactive oxygen species (ROS) has been studied. This report shows that conducting polymers can therapy influenza A virus-infected MDCK cells by controlling intracellular ROS levels. We infected the MDCK cells with influenza A viruses (IV), H1N1, H3N2, and H9N2 and treated the infected cells with particles composed of conducting polymers: poly pyrrole, poly aniline and poly(aniline-co-pyrrole) (PASome). The results show that viral infection induces intracellular ROS levels increased and the particles reduce the ROS levels by deoxidizing ROS. MEK/ERK/Nur77 signal expression was inhibited, and the cell viability was increased significantly. Consequently, these results demonstrate that PASome showed the best control efficiency. |
| 저자 | 김지혜1, 김현욱1, 임종우1, 윤다연1, 천해진1, 박근선1, 이훈재1, 나운성2, 염민주2, 함승주1, 송대섭2 |
| 소속 | 1연세대, 2고려대 |
| 키워드 | 고분자합성; 기능성고분자; 바이오고분자 |
| 원문파일 | 초록 보기 |
