| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Novel Gas-Generating Mineralized Nanoparticles for Ultrasound Imaging Guided Tumor Therapy |
| 초록 |
Ultrasound (US) is a real-time and non-invasive imaging modality that is widely available to visualize anatomical structures of tissues and organs. Conventionally, gas-filled microparticles have been used as contrast agents for ultrasound imaging. However, these types of contrast agents have limitations for intravenous applications particularly in tumor imaging, because they lack of prolonged circulating properties, which result in low permeation to tumor tissues. In this work, we have developed gas-generating mineralized nanoparticles (GGMNPs) that can generate nanobubbles for US imaging of tumors. We demonstrated the generation of carbon dioxide bubbles from the GGMNPs in acidic cellular pH. To demonstrate US imaging of a tumor, we administered an intratumoral injection of the GGMNPs dispersion to tumor-bearing nude mice and compared US images between pre- and post-injection. The tumor volume was also monitored in tumor-bearing nude mice for antitumor efficacy of DOX loaded GGMNPs. |
| 저자 |
민경현1, 민현수2, 김광명2, 권익찬2, 정서영1, 이상천1
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| 소속 |
1경희대, 2한국과학기술(연) |
| 키워드 |
Mineralized nanoparticles; Ultrasound imaging; Gas-generating; Tumor terapy
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| E-Mail |
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