| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표) |
| 제목 |
Dextran Sulfate Based Nanoparticles for Atherosclerosis Imaging |
| 초록 |
Atherosclerosis is a systemic disease that is characterized by the build-up of lipid-rich plaques within the walls of the arteries. Early detection of these vulnerable plaque could significantly reduce the morbidity. Dextran sulfate, a polyanionic derivative of dextran, acts as a ligand for macrophage scavenger class A, a receptor over-expressed on matured macrophages in the atherosclerotic region. In this study, dextran sulfate-coated nanoparticles were prepared as the potential imaging agent for atherosclerosis. The physicochemical properties of the nanoparticles were investigated using various instruments, including 1H NMR, FT-IR, transmission electron microscope, and dynamic light scattering. The results demonstrated rapid uptake of the dextran sulfate-based nanoparticles by activated macrophage. |
| 저자 |
유동길1, 윤홍열1, 전상민1, 김광명2, 권익찬2, 박재형1
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| 소속 |
1성균관대, 2한국과학기술(연) |
| 키워드 |
Nanoparticles; Dextran Sulflate; Atherosclerosis
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| E-Mail |
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