| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.280 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of Binder and Other Excipients on the Dissolution and Storage Stability of Lansoprazole-loaded Alginate Granule |
| 초록 | Sodium alginate has been widely used in a variety of oral and topical pharmaceutical formulations. It promotes gelation by chelation with metal ion such as calcium chloride due to its specific molecular structure. We used lansoprazole as a model drug, therapeutics for gastric ulcer and duodenal ulcer, and prepared granules by encapsulating the drug with sodium alginate. Lansoprazole is so unstable in acid that degrades before it reaches small intestine, and its storage stability seems to be worsen because of outer moisture. So, it needs to devise the process to acquire the gastric resistance and storage stability. In this study, we used hydroxy propyl starch and sodium algnate as film former and varied the amount of binder and other factors and evaluated the effect of those factors on the dissolution and storage stability. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-050-2A). |
| 저자 | 김정훈1, 오정민2, 정제교*3, 강길선, 이종문, 이정식*, 이해방** |
| 소속 | 1전북대, 2*삼천당제약 중앙(연), 3**한국화학(연) |
| 키워드 | |
