| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.62 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Electrospun Dual-Porosity Structure and Biodegradation Morphology of Montmorillonite Reinforced PLLA Nanocomposite Scaffolds |
| 초록 | Recently, the potential of electrostatic fiber spinning, or electrospinning, has been focused as an alternative scaffold fabrication technique in soft-tissue cell transplantation and hard-tissue regeneration. However, the electrospinning method has a difficulty in controlling the pore size in scaffold applications especially when relatively large-sized pores are required, for example, in the range of few hundred micrometers. In addition, the electrospun membrane may be too soft to be utilized as a hard-tissue scaffold system like bone regeneration application. In this study, the exfoliated MMT/PLLA solution was electrospun to provide MMT-reinforced PLLA nanofibers, which were subsequently mixed with NH4HCO3/NaCl salt particles and mechanically entangled by a cold compression-molding process in a solid state. After leaching out the salts, the resultant solid scaffolds exhibited a robust porous structure containing a dual-porosity network in the ranges of few nanometers and few-hundred micrometers. The exfoliated peak of the PLLA/MMT nanocomposite from XRD was confirmed. The surface morphology of PLLA/MMT nanocomposite was measured by scanning electro microscope. The resulting scaffold structure exhibits dual-porosity structure of the macro-sized and nano-sized pores. The molecular weight and molecular weight distributions of PLLA/MMT nanocomposite were measured by gel permeation chromatography. The molecular weight of scaffolds drops in the range of 2-15 days from 110,000 to 10,000. |
| 저자 | 이윤희1, 이종훈1, 안인구1, 김찬2, 이두성1, 이영관1, 남재도1 |
| 소속 | 1성균관대, 2전남대 |
| 키워드 | electrospinning; scaffold; fiber |
