| 초록 |
Hyaluronic acid (HA) has currently several therapeutic applications due to relevant advantages of biocompatible, biodegradability, and specific targeting on cancer cell. We focused on core-shell formation with silica particle and dopamine modified HA (HA-DA). The particles` shape and formation were measured by DLS, AFM, SEM, and Bio-TEM. The process was performed on different pH conditions in order to investigate the optimum pH for core-shell formation. It was found that the redox state of dopamine is a key factor to modulate the particle size and shape by competition of adhesive and cohesive properties. The chemical composition of HA-DA with pH was analyzed by FT-IR and XPS. After HF treatment on silica core, the hollow HA-DA particles were successfully activated as a carrier of anticancer drug, doxorubisin (DOX). The loaded DOX in hollow particles exhibited 82.1% releasing quantity at pH 5.5 compare to 25.5% at normal physiological condition. |
