| 초록 |
In this study, we have produced ion chelated polymeric nanoparticle for cancer imaging and therapy. Ion chelated polymeric nanoparticles were prepared using a solvent emulsion evaporation method to load chlorin e6 (Ce6) and gadolinium (Gd+3). Loaded Ce6 molecules maintained their spectroscopic and functional properties for near infrared fluorescence imaging and photodynamic therapy (PDT). Gadolinium chelated hyaluronic acid coating on the PLGA particle surface and offered the functions of magnetic resonance imaging (MRI). We characterized the physicochemical properties of nanoparticles, efficacy of PDT , fluorescence and MRI imaging performance. These results suggest that ion chelated polymeric nanoparticles have potential for effective cancer treatment and imaging. |
