| 초록 |
To create efficient photosensitizers for photodynamic therapy (PDT) with a higher photocytotoxicity and selectivity to the diseased tissue, a great number of challenges have been accomplished. To obtain high quantum yields and effective energy absorption, photosensitizers generally need to have large π conjugation domains. Therefore, most of conventional photosensitizers easily form aggregates, which produce a self-quenching effect of the excited state, in aqueous medium due to their π-π interaction and hydrophobic characteristics. Based on this information, we have prepared ionic dendrimer porphyrins and phthalocyanines as potential candidates of efficient photosensitizer for PDT. Dendrimers showed the promising feature as a photosensitizer for PDT, because dendrimers exhibit a high solubility in an aqueous medium and have a high quantum yield for singlet oxygen generation. Furthermore, charged ion surface can form polyion complex micelles by means of electrostatic interaction with oppositely charged block copolymer. These types of polyion complex micelles with PEG shell were demonstrated to accumulate effectively and specifically in solid tumor tissue. |
