| 초록 |
Multiplexing of molecules with high sensitivity and selectivity is an essential technology in clinical diagnostics, environmental monitoring, and food safety. So far, various biosensing assays based on fluorescence and electrochemical response have been developed to achieve multiple detection. However, limitations in resolution and lack in specificity are issues yet to be overcome. Surface-enhanced Raman scattering (SERS) provide characteristic signals from targets and display single-molecule level sensitivity, and thus have drawn much attention for sensor applications. In this study, we propose a sensor based on aptamer-functionalized SERS for improved resolution and selectivity in multiplexing operations of organic pollutants. Raman and XPS analysis confirm successful immobilization of aptamers onto Au nanostructures. Raman spectra of singular and multiplex detection show promising results for applications in real environment. |
