| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation and Anticancer effect of Paclitaxel-loaded Chitosan-b-PCL nanoparticle for Cancer Therapy |
| 초록 |
The aim of this study was to deliver drug using chitosan-b-PCL di-block copolymer. The di-block copolymer was synthesized by radical polymerization. It has an advantage which free amine group of chitosan can increase cell uptake because of enhancement of charge interaction between copolymer and cancer cell. The characterization of chitosan-b-PCL di-block copolymer was analysed by 1H-NMR, FT-IR, CMC, DLS, and TEM. Also, content and release of loaded paclitacxel into chitosan-PCL were confirmed by UV. In addition, Its cytotoxicity and anticancer activity was confirmed by MTT assay. These results suggest that di-block copolymer can be able to apply as drug carrier. This research was supported by The Leading Human Resource Traning Program of Regional Neo industry through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning(grant number) (NRF-2016H1D5A1910499). |
| 저자 |
정경원, 정은희, 남충현, 박준영, 최창용, 나재운
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| 소속 |
순천대 |
| 키워드 |
chitosan; PCL; chitosan-b-PCL block copolymer; antitumor activity
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| E-Mail |
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