| 초록 |
In this study, we present a novel strategy for on-cue detachment of bioactive heparin-based hydrogels from optically transparent ITO electrodes. Electrode array was employed to exercise spatiotemporal control over the detachment of hydrogels from the individually addressable ITO. Micropatterned ITO by using photolithography was modified with vinyl- functionalized silane and then heparin hydrogels were aligned on the ITO. Application of a reductive potential (-1.8 V) resulted in detaching hydrogels from the electrodes. Thus, the specific location and the time point of detaching the hydrogels from ITO could be modulated by an electrical signal. In addition, this electrochemical release method was used to detach hydrogels with cells and was found to cause minimal damage to the cells. Therefore, a novel electrochemical strategy that allows to selectively releasing of cells and biomaterials from the electrodes will open new opportunities for cell analysis and tissue regeneration. |
