| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Self-assembled HSA-PEG/PTX nanoparticles for antitumor treatment |
| 초록 | Paclitaxel (PTX) is a potent chemotherapeutic agent used for the treatment of a broad range of advanced carcinomas. However, the solubility of PTX limits uses of the drug. Oil and methanol mixture was used to improve its solubility in most cases, but they also bring side effects. Herein, a facile and oil-free method was used via a conjugate of human serum albumin (HSA) and poly(ethyleneglycol) (PEG). The HSA-PEG/PTX can be readily self-assembled with film casting and re-hydration. And the PEGylation of HSA would increase the solubility of the protein at the same time. The result suggests a potent platform for the dissolution of various poorly water-soluble drugs in aqueous media. |
| 저자 | LYU SIYAN, 정지훈, 김다훤, 임수연, 황위보, 김병덕, 박채은 |
| 소속 | 성균관대 |
| 키워드 | polymer; nanoparticle |
