| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
PEGylated Albumin-based nanoplatforms for cancer chemotherapy |
| 초록 |
Paclitaxel(PTX) is chemotherapy medication used to treat recurrent and metastatic breast cancer, which has high effect and low solubility. PTX needs oil/detergent-based solvent to be dissolved since to its poor solubility in an aqueous environment. However, those formulations frequently cause undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose than recommended dose. Now, we introduce a facile and oil free method to prepare albumin-based PTX nanoparticles for efficient systemic cancer therapy using a conjugate of human serum albumin (HSA) and PEG. PTX were efficiently incorporated in the self-assembled PEGyl-HSA nanoparticles using a simple film casting and re-hydration procedure without additional processes such as application of high pressure/shear or chemical crosslinking. The PEGyl-HSA nanoparticle mediates efficient cellular delivery, leading to higher cytotoxicity in various breast cancer cells . |
| 저자 |
김병덕, 임수연, 김다훤, 박채은, 황위보, LYU SIYAN, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
human serum albumin; oil-free formulation; systemic delivery; self-assembled nanoparticle
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| E-Mail |
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