| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Folic acid modified bovine serum albumin nanoparticles combining chemo-photodynamic therapy is effective treatment for cervical cancer |
| 초록 |
We developed the folic acid modified bovine serum albumin-based nanoparticles loaded DOX and Ce6 to solve the problem. Confocal microscopy analysis further validated cellular uptake of FA-Ce6/DOX/BNPs by HeLa cells. Moreover, FA-Ce6/DOX/BNPs potentiated mitochondrial reactive oxygen species production in HeLa cells under 671-nm laser exposure, leading to activation of key regulator proteins of apoptosis. Furthermore, we evidenced by gene/protein expression level of apoptotic/anti-apoptotic biomarkers by real time quantitative PCR and western blot analysis. FA-Ce6/DOX/BNPs use in chemo-photodynamic combination therapy with FA as a target cancer cell receptor may provide more effective anti-cancer effects with decreased side effects in cervical cancer. |
| 저자 |
김관우1, 김수헌1, 이후민1, Shruti Shukla2, Vivek K. Bajpai3, 한영규3, 허윤석1
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| 소속 |
1인하대, 2National Institute of Food Technology Entrepreneurship and Management, 3동국대 |
| 키워드 |
chemotherapy; photodynamic therapy; BNPs
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| E-Mail |
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