| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Development and characterization of propolis extract, camellia oil extract, oil soluble licorice Extract encapsulated polymeric micelle nanoparticle material |
| 초록 |
Propolis extract, Camellia oil extract, and oil soluble licorice extract are difficult to be applied due to its low water solubility despite its well-known efficacy. In this study, polymeric nanomicelle material containing three extracts was prepared using biocompatible polymer. Prepared nanomicelle material was stable when stored at 40°C for 3months and RT for 6 months. The particle size analysed by DLS was 17nm to 21nm. The encapsulation rate of propolis and glabridin analyzed by HPLC were 99.49% and 98.93% each. Total skin permeability after 24 hours was 8.67% for the control group and 18.87% for the polymeric nano micelle material group. Tyrosinase inhibition assay, DOPA oxidation inhibition assay, melanin production test assay, hyaluronic acid test assay in the cell, synthesis of collagen and inhibition of collagenase assay were conducted and the result of nanomicelle group were higher in comparison. This study was funded by Korea Institute for Advancement of Technology(P0006163) |
| 저자 |
안주영1, 조선행2, 김채진1, 박나래1, 이은희3
|
| 소속 |
1한국화학(연), 2고려대, 3중앙대 |
| 키워드 |
polymeric micelle; biocompatible polymer; nanoparticle
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| E-Mail |
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