| 초록 |
Herein, we successfully fabricated and characterized a controllable photothermal disulfide cross-linked pH/redox-responsive polymer dot for an off/on bioimaging probe and near‐infrared (NIR)‐mediated chemotherapy. Folic acid (FA) was conjugated to carbon dots which further attached with photothermal agent utilizing electrostatic interaction. Due to a FA receptor, the cationic-mediated endocytosis happened, the ICG-CD easily incorporated within the cytoplasm of cancer cells. The encounter of ICG-CD with high concentration of the intracellular GSH recovered the fluorescence as a result of GSH-disulfide redox reaction. Moreover, ICG was controllably released from CD matrices which beneficial for photothermal therapy under NIR irradiation. In conclusion, the results suggested that ICG-CD had huge possibility for controllable therapeutic delivery especially in diagnosis and imaging. |
