| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
All-trans retinoic acid encapsulated chitosan nanoparticles based on polyelectrolyte complexes |
| 초록 |
The purpose of this study is to develop novel nanoparticles based on polyion complex formation between low molecular water-soluble chitosan(LMWSC) and all-trans retinoic acid (atRA). LMWSC nanoparticles encapsulating atRA based on polyion complex were prepared by mixing of atRA into LMWSC aqueous solution using ultra-sonication. At FT-IR spectra, the carbonyl group of atRA at 1690 cm-1 disappeared or decreased when ion complexes were formed between LMWSC and atRA. At 1H NMR spectra, specific peaks of atRA disappeared when atRA-encapsulated LMWSC(RAC) nanoparticles were reconstituted into D2O while specific peaks both of atRA and LMWSC appeared at D2O/DMSO (1/3, v/v) mixture. XRD patterns also showed that crystal peaks of atRA were disappeared by encapsulation into LMWSC nanoparticles. LMWSC nanoparticles encapsulating atRA have spherical shapes with particle size below 200 nm. LMWSC nanoparticles showed high atRA loading efficiency over 90 % (w/w). |
| 저자 |
김동곤1, 정영일1, 장미경1, 박준규1, 장학수1, 장민자1, 권중근2, 서동혁1, 나재운1
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
all-trans retinoic acid; chitosan;
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| E-Mail |
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