| 초록 |
In this work, Naproxen imprinted satrch based biomaterials were synthesized using allbanggae starch (ABG), polyvinyl alcohol (PVA), naproxen (NP), sodium benzoate as a crosslinker, and glycerol (GL) as a plasticizer. The biomaterials were prepared by UV curing process, and then evaluated physical properties such as tensile strength (TS), elongation at break (%E), swelling behavior (SB), and solubility (S). In addition, the prepared biomaterials were characterized by FE-SEM and FT-IR. NP release properties of biomaterials were performed using standard buffer solutions and artificial skin at 36.5℃, respectively. Results of NP release properties indicated that degree of NP release in low pH was faster than in high pH. In case of NP release using artificial skin, NP was released sustainedly for 6 h. From the results, we suggest that NP imprinted biomaterials can be applied as a transdermal drug delivery patch for anti-inflammatory painkilling. |
