| 초록 |
In this study, we fabricated polysaccharide based multilayer films coated TiO2 particles for cancer therapy. We constructed Chitosan (CHI)/hyaluronic acid (HA) multilayer films, where HA is well-known for its binding ability with over-expressed CD44 on cancer cells and CHI has free chain which induce vacancy in multilayer films. Then we diffused doxorubicin which is anticancer drug into the CHI/HA multilayer films. We focused on improving drug incorporation capacity within film layers. So we controlled morphology of multilayer films as exponentially growth manner. Exponential growth film has free chain that drugs can diffuse through multilayer films. Due to the free chain inducing vacancy in multilayer films, a large quantity of doxorubicin can be loaded. We confirmed the anticancer effect of doxorubicin-loaded multilayer films on TiO2 particle. Both photokilling of TiO2 particles under UV and doxorubicin increased the anticancer effect. |
