| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Curcumin polymeric micelles as inhibitor of the Wnt/beta-catenin signaling pathway target colon cancer |
| 초록 |
In this study. we describe the formulation, characterization and bio-activity of polymeric micelles conjugating the curcumin. Polysuccinimide (PSI) was synthesized. hydrophobic octabecylamine (C18) and hydrophilic O-(2-aminoethyl) polyethylene glucol were grafted on a PSI backbone. Folic acid was used as targeted ligand. Two different formulations: Folate-PEG-Hyd-Curcumin/C18-PSI (FA-Cur) and PEG/Hyd-Curcumin/C18-PSI (NFA-Cur) micelles were tested. The characterization was expressed by H-NMR. The cytoxicity was performed by MTT assay. The effective therapy was confirmed on SW480 colon cancer cells. The results also confirmed that FA-Cur inhibited the target genes, cyclin D1 and c-myc. Taken togethe, FA-Cur micelles are a promissing candidate for colon anto-cancer through inhibiting Wnt/beta-catenin signaling pathway. |
| 저자 |
레티뜨엉, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
Polymeric micelles; Wnt/beta-catenin; colon cancer; Curcumin
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| E-Mail |
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