| 초록 |
Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents and wound dressings aiming to replace conventional sutures. For prevention of immune response and serious inflammation from the hydrogels after sealing, natural polysaccharide is widely used, yet weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels still allow augmentation by suture threads. Here, a solid polysaccharide thread reversibly crosslinked by boronic acid-polyphenol interaction is reported for sealing without such augmentation. The thread shows spontaneous phase transition to swollen adhesive hydrogels depending on the existence of body fluid after suturing. In particular, the acidity of the body fluid could affect the viscoelasticity and adhesiveness of the swollen hydrogels, leading to tight sealing as a function of pH. Our finding to design a pH-responsive thread would be promising for developing on-demand functional suture materials. |
