| 초록 |
Continuous intraocular pressure (IOP) monitoring can provide a paradigm shift in the management of patients with glaucoma as a facile alternative for the conventional diagnostic methods. However, the low sensitivity and functional instability of IOP sensors has limited the practical applications of smart IOP contact lenses for glaucoma. Here, we have developed a smart contact lens integrated with a transparent silver nanowire (AgNW) IOP strain sensor and wireless circuits for non-invasive, continuous IOP monitoring. After confirming the robust stability of the IOP sensor in the smart contact lens in tears and eyelid blink model cycles, we monitored IOP changes on polydimethylsiloxane (PDMS) model eyes in vitro. In vivo tests demonstrated that our fully integrated wireless smart contact lens could successfully monitor the change of IOP in living rabbit eyes. Taken together, we could confirm the feasibility of smart contact lens as a non-invasive platform for IOP monitoring of glaucoma. |
