| 초록 |
In search of a new biomaterial, modifications of a material by cell membrane components can be an attractive strategy. Noting that the major components of cell membranes are zwitterionic molecules, zwitterionic polymers have been investigated as surface-coating materials due to their low protein adsorption properties, which reduce immunogenicity, biofouling, and bacterial adsorption of coated materials. Most zwitterionic polymers are based on (meth)acrylate polymers which can induce toxicity by residual monomers or amines produced by degradation. Here, we report a new zwitterionic polymer consisting of phosphorylcholine (PC) and poly(propylene glycol) (PPG) as a new thermogelling material. The PC-PPG-PC polymer aqueous solution undergoes unique multiple sol-gel transitions as the temperature increases. Based on the broad gel window and low protein adsorption properties, the PC-PPG-PC thermogel is proved as biocompatible systems for sustained delivery of protein drugs and stem cells. |
