| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | pH-sensitive Metal-organic framework covered with cancer targetable carbohydrates-photosensitizer nanoplatform for in vivo generated cancer vaccine |
| 초록 | Cancer vaccine is a promising approach to overcoming tumor’s immunosuppression and activation T cells in response to tumor-specific antigen (TSA). However, limitations such as the diversity of TSAs and finding immunogenic TSAs prior to cancer vaccine treatment hinder the development of cancer vaccines. Here, we suggest pH-sensitive metal organic framework, covered with cancer targeting carbohydrates conjugated with photosensitizer (pMOFCP). This nanoparticle induces cancer necrosis and released TSA promotes in vivo generated cancer vaccine (ICV). pMOFCP showed effective antitumor immune response through FACS analysis of T cells and DCs’ maturation number. No specific side effect was detected with H&E staining of major organs and serum test. Tumor growth inhibition of pMOFCP was observed with H&E staining assay in cancer bearing mice. Our research demonstrates a new immune regulating nanoparticle and has potential to expand the variation of cancer immunotherapy |
| 저자 | 이현승, 신희준, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | cancer vaccine; metal organic framework; photodynamic therapy; immunotherapy |
