| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Catechol-immobilized nanofiber for enhancing attachment and migration of cells |
| 초록 |
Catechol has a strong adhesiveness with surface of substrates. Also, the catechol could bind with thiol groups of various amino acids by Michael-type addition at basic condition because the dihydroxy group transform into diketone group. Almost dihydroxyphenyl group has a limitation of adhesiveness after polymerization of catechol. Therefore, in this study, nanofiber was surface-immobilized [CNF] with a single molecule of catechol to enhance cell adhesiveness of the nanofiber. NIH 3T3 fibroblasts were cultured on CNF to confirm a cells adhesion in DMEM without serum at pH 7.4 for 3 h. Among of the nanofibers, CNF showed about 5-fold higher of cells adhesion compared to NF. It was expected that catechol on the nanofiber could induce an adhesion of cells because the catechol interact with thiol-group of surface-proteins on cell membrane. This CNF showed a superior incorporation of thiol groups, also, significantly stimulated adhesion and migration of cells compared with NF. |
| 저자 |
윤수진1, 최지숙1, 김혜성1, 손영주1, 조은주1, 김영희1, 강지현1, Phillip B. Messersmith2, 유혁상1
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| 소속 |
1강원대, 2Northwestern Univ. |
| 키워드 |
catechol; nanofiber; attachment; migration
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| E-Mail |
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