| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II (영어발표) |
| 제목 |
Large-scale Production and Therapeutic Compound Regulation of Extracellular Vesicles via 3D Stem Cell Bioprocess Using Biopolymers |
| 초록 |
As a lipid-shielded and nano-sized vesicle retaining medicinal potency equivalent to that of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicle (EV) is preferred over the current MSC infusion therapy with improved safety profiles, considered an ideal therapeutic candidate for regenerative medicine. However, conventional MSC culture methods are problematic to obtain sufficient amounts of EVs for clinical application. In addition, as primed for a targeted disease, desired recruitment of the multifaceted therapeutic compounds in EVs should be addressed. In this talk, I will introduce efficient 3D stem cell bioprocessing techniques using biopolymers, which are 1) a microwell culture platform composed of polyethylene glycol hydrogel that successfully reached significant enrichment of MSC-derived EVs, and 2) 3D-organization of different physical interactions between MSCs and culture matrices using gelatin methacryloyl hydrogel to regulate cytokine inclusions packaging into EVs. |
| 저자 |
차재민1, 정선영2, 김태희1, 배호재3, 김진석2, 방오영1
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| 소속 |
1삼성서울병원, 2한국과학기술(연), 3건국대 |
| 키워드 |
Extracellular Vesicle; Mesenchymal Stem Cell; Regenerative Medicine; Bioprocess
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| E-Mail |
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