| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System facilitates osteogenic differentiation of Human Mesenchymal Stem Cells |
| 초록 |
Human mesenchymal stem cells (hMSC) are one of the stem cells that have multipotent properties. Despite their boundless possibility, current use of hMSCs in clinics is still limited because differentiation of hMSCs to desired cells is often difficult to control especially in vivo situation. Herein, biologically acceptable calcium phosphate (CaP)-based nanoparticles stabilized with a catechol-derivatized hyaluronic acid (dopa-HA) conjugate were used as a carrier for gene transfection to hMSCs for improved differentiation. Owing to the specific binding between HA and CD44 of bone marrow-derived hMSCs, dopa-HA/CaP showed significantly higher transfection in hMSCs than branched polyethylenimine (bPEI, MW 25 kDa) with high biocompatibility. The co-delivery of a plasmid DNA encoding bone morphogenetic protein 2 (BMP-2 pDNA) and micro RNA 148b (miRNA-148b) by dopa-HA/CaP successfully achieve improved osteogenic differentiation of hMSCs. |
| 저자 |
조희주, 정재백, 임수연, 김다훤, 김동민, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Gene Delivery System; Human Mesenchymal Stem cell; osteogenic differentiation
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| E-Mail |
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