| 초록 |
Polyelectrolyte complexes (PEC) have been studied for many years as fundamental research for biological applications such as DNA vectors. However, PECs often form precipitates due to charge compensation, which restricts their applications in the biomedical field. Herein, we prepared PECs based on poly(N-isopropylacrylamide)-b-poly(styrene) block copolymer micelles with pyridine-ends on the PNIPAM block sides and negatively charged polyelectrolytes, poly(sodium 4-styrenesulfonate) (NaPSS). These novel PECs were well-dispersed due to the charge inversion, maintaining the dispersed state at temperature above LCST of PNIPAM. We investigated these properties as functions of molecular weight of PSS, pH to control the interactions. Having investigated PECs between these micelles and charged particles, we also identified unique complexation behavior between them. We hope that our finding can be extended to clarify the PEC formation and to understand the biological phenomena in general. |
