| 초록 |
Titanium dioxide (TiO2), easily formed when titanium derivatives are exposed to water, has been used for various fields, such as sun cream and food additive, with its biocompatibility. Crystalline TiO2 can function as a photocatalyst to produce reactive oxygen species (ROS) under light irradiation in solution. The generated ROS can damage biomolecules including DNA, which results in cytotoxicity of tumor cells. Although there are many studies to incorporate the photoactivation with drug delivery systems, there are few studies to control the photoactivity depending on a specific condition. Herein, we developed means to synthesize core-shell structured nanoparticles of TiO2 with a shell of calcium phosphate (CaP). The pH-responsive decomposition of the CaP shell can control the release of drugs and the activity as photocatalysts. Results of preparation for the core-shell structured nanoparticles, and drug delivery and photoactivity depending on pH will be discussed in the presentation. |
