| 초록 |
Drug delivery through contact lens is an attractive method for the delivery of ophthalmic drugs, but there are limitations such as limited drug loading capacity and an initial burst of drugs. To improve this limitations, we developed cholesteryl-hyaluronic acid micelle embedded contact lenses to allowing hydrophobic drugs to be loaded more efficiently and released for long time. The contact lens was fabricated through photopolymerization of HEMA and EGDMA as a cross-linker. The effect of micelle on contact lens properties such as transmittance, wettability and mechanical strength were studied. In vitro drug release tendency from the contact lenses were analyzed over 12 days, and the in vivo treatment effect was confirmed through schirmer tear test, corneal fluorescein staining, MMP9 fluorescein analysis in dry eye diseases rabbit model. |
